Pair Name	Arachidin-1, Paclitaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induced-->Mitochondrial oxidative stress
Gene Regulation	Up-regulation	Expression	TP53	hsa7157
	Down-regulation	Expression	BIRC5	hsa332
	Up-regulation	Cleavage	CASP7	hsa840
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
	MDA-MB-436	Invasive breast carcinoma	Homo sapiens (Human)	CVCL_0623
Result	A-1 in combination with Pac inhibited cell proliferation, induced apoptosis through mitochondrial oxidative stress, and reduced TNBC spheroid growth. These findings underscore the impactful effects of the prenylated stilbenoid A-1 as a novel adjuvant for Pac chemotherapy in TNBC treatment.